iNOS是什么？
iNOS为诱导型一**氮合酶。
具体如下：
一**氮合酶(NOS)是一种同工酶，分别存在于内皮细胞、巨噬细胞、神经吞噬细胞及神经细胞中。一**氮合酶存在于神经元中，在不同脑区呈选择性分布。因为一**氮很不稳定，因而研究生成一**氮的酶似乎更容易些，特别是一**氮合酶拮抗剂的发现，大大促进了一些一**氮功能的研究。
一**氮合酶一**氮合酶于神经系统，其同功酶有三种亚型，即在正常状态下表达的神经元型一**氮合酶(nNOS)和内皮型一**氮合酶(eNOS)以及在损伤后诱导表达的诱导型一**氮合酶(iNOS)。来源于诱导型一**氮合酶和神经元型一**氮合酶的一**氮合酶有神经毒性作用，来源于内皮型一**氮合酶的一**氮有神经保护作用。其中以海洋生物为主要原料提取出来的酶一种内皮一**氮合酶 学术名称:”一**氮海洋合酶” (NOSS)，这种酶的活性更高，可以在增强体内一**氮循环机制作用，源源不断的产生一**氮。但是这种酶很少见，必须是由海洋生物尖海龙、牡蛎、鱼精蛋白等海洋珍贵物种才能取提产生出来。
nNOS(NOS1)和eNOS(NOS3) 为钙依赖型，iNOS(NOS2)为钙非依赖型。nNOS也存在于心肌组织中，NOS以L-精氨酸为底物，利用氧生成NO和L-瓜氨酸。诱导型一**氮合成酶，是机体nos活性氮自由基产生的催化酶。
具体其含量的高低可能最为一种机体内炎症程度的指标，生物学可以，不知道临床医学。
蛋白库 pdb的解释
produces nitric oxide (no) which is a messenger molecule
with diverse functions throughout the body. in macrophages, no mediates
tumoricidal and bactericidal actions. also has nitrosylase activity and
mediates cysteine s-nitrosylation of cytoplasmic target proteins such
cox2. homodimer. binds slc9a3r1. by endotoxins and cytokines. induced by
ifng/ifn-gamma acting synergistically with bacterial
lipopolysaccharides (lps), tnf or il1b/interleukin-1 beta. expressed in
the liver, retina, bone cells and airway epithelial cells of the lung.
not expressed in the platelets. regulated by calcium/calmodulin. aspirin
inhibits expression and function of this enzyme and effects may be
exerted at the level of translational/post-translational modification
and directly on the catalytic activity. belongs to the nos family. 2
isoforms of the human protein are produced by alternative splicing.
note: this description may include information from uniprotkb.
protein type: ec 1.14.13.39; amino acid metabolism – arginine and proline; oxidoreductase
cellular component: cortical
cytoskeleton; extracellular space; perinuclear region of cytoplasm;
cytoplasm; peroxisome; vesicle membrane; intracellular; nucleus; cytosol
molecular function: protein
homodimerization activity; fad binding; nitric-oxide synthase activity;
metal ion binding; beta-catenin binding; camp-dependent protein kinase
regulator activity; oxidoreductase activity; hsp90 protein binding;
actin binding; protein kinase binding; calmodulin binding; protein
binding; fmn binding; nadph-hemoprotein reductase activity; cadherin
binding; iron ion binding; heme binding; nitric-oxide synthase binding;
nadp binding; receptor binding
biological process: superoxide
metabolic process; response to lipopolysaccharide; positive regulation
of guanylate cyclase activity; positive regulation of killing of cells
of another organism; positive regulation of vasodilation; ovulation from
ovarian follicle; regulation of cell proliferation; defense response to
bacterium; peptidyl-cysteine s-nitrosylation; response to hypoxia;
arginine catabolic process; negative regulation of blood pressure;
regulation of protein kinase activity; inflammatory response; negative
regulation of protein catabolic process; nitric oxide biosynthetic
process; regulation of insulin secretion; nitric oxide mediated signal
transduction诱导型一**氮合成酶，是机体NOS活性氮自由基产生的催化酶。
具体其含量的高低可能最为一种机体内炎症程度的指标，生物学可以，不知道临床医学。
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